
I upgraded to OS 10.4.4 a couple of days ago, and this morning discovered that PhpMyAdmin was telling me it couldn't connect to the database despite the fact that I knew mysqld was running, and accessible via the command-line client.
Fortunately, the fix is very simple - edit your /etc/php.ini (or create it, if it doesn't exist) file and make sure the mysql.default_socket line looks like this:
mysql.default_socket =/tmp/mysql.sock
I found this and other 10.4.4 fixes on this Macfixit.com page.
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